Instruction in peer assessment of complex task performance may cause high cognitive load, impairing learning. A stepwise instructional strategy aimed at reducing cognitive load was investigated by comparing it with a combined instructional strategy in an experiment with 128 secondary school students (mean age 14.0?years; 45.2% male) with the between-subjects factor instruction (stepwise, combined). In the stepwise condition, study tasks in Phase 1 were domain-specific and study tasks in Phase 2 had both domain-specific and peer assessment components. In the combined (...) condition, these two components were present in all tasks in both phases. Final performance (i.e. speed and accuracy in domain-specific skills and peer assessment skills) showed no significant differences, but performance improved more from Phase 1 to Phase 2 in the stepwise condition than in the combined condition. The results suggest that, with complex study tasks, it might be beneficial to teach domain-specific skills before peer assessment skills. (shrink)

Genomic research projects that collect tissues from deceased organ and tissue donors must obtain the authorization of family decision makers under difficult circumstances that may affect the authorization process. Using a quasi-experimental design, the Ethical, Legal, and Social Issues (ELSI) substudy of the Genotype-Tissue Expression (GTEx) project compared the recall and understanding of the donation authorization process of two groups: family members who had authorized donation of tissues to the GTEx project (the comparison group) and family members who had authorized (...) organ and tissue donations in years previous, who subsequently participated in two different mock-authorization processes that mimicked the GTEx authorization process (the intervention groups). Participants in the comparison and intervention groups were matched on key demographic characteristics.We found that participants in the intervention groups who experienced a mock-authorization process demonstrated better recall of the tissue donation request than members of the comparison group. Our data indicate that the stress associated with the loss of a loved one limited the ability of family members to recall details about the GTEx project. However, we found a similar lack of knowledge in both the comparison and the intervention group participants, suggesting lack of knowledge may be due to the complexity and unfamiliarity of the information presented to them during the authorization process. We discuss these findings in the context of everyday clinical decision making in cognitively challenging conditions. (shrink)

Johanna Knapstein,1 Daniel Grimm,1 Marcus A Wörns,1 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann111st Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany; 2Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg-University, Mainz, GermanyIntroduction: Hepatitis C virus reinfection occurs universally after liver transplantation, with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Dual antiviral therapy with pegylated interferon-2a and ribavirin only reaches sustained virological response rates of ~30% after liver transplantation. With the approval of viral NS3/4A (...) protease inhibitors telaprevir, boceprevir, and simeprevir and the NS5B polymerase inhibitor sofosbuvir, combination therapy offers new therapeutic options for HCV-infected patients, resulting in considerably higher sustained virological response rates in the nontransplant setting. Case presentation: We report three cases of TVR-based triple antiviral therapy in HCV genotype 1 reinfected patients after liver transplantation, of whom a 57-year-old Caucasian female and a 43-year-old Caucasian male were therapy naïve, and a 49-year-old Caucasian male patient was pretreated ineffectively. After 4 weeks of therapy, viral load decreased one to three log10 and became negative in weeks 6 to 8 in the therapy naïve patients. The pretreated patient showed a negative viral load in week 4. TVR was administered over 12 weeks, 750 mg thrice daily. Doses of immunosuppression with cyclosporine were reduced four to six fold. Initial peg-IFN and RBV doses ranged from 135–180 µg/week and 800–1,200 mg/day, according to the patient's body weight. Doses of peg-IFN and RBV were adapted to 90–135 µg/week and 400–800 mg/day after 2 to 12 weeks of protease inhibitor therapy. Dual therapy was continued for 36 weeks with total treatment duration of 48 weeks in the therapy naïve patients leading to a sustained virological response 12 weeks after the end of therapy. In the pretreated patient a breakthrough was detected in week 24 and therapy was discontinued. Overall, antiviral therapy was well tolerated. Side effects included dysgeusia and anemia leading to erythropoietin application and blood transfusions. Conclusion: This case series emphasizes that triple therapy with TVR is an efficient treatment for therapy naïve HCV genotype 1 reinfected patients after liver transplantation. But therapeutic options for pretreated patients require improvement. Keyword: cyclosporine, interferon, ribavirin, hepatitis C, protease inhibitor. (shrink)

The COVID-19 pandemic has resulted in more than 524 million cases and 6 million deaths worldwide. Various drug interventions targeting multiple stages of COVID-19 pathogenesis can significantly reduce infection-related mortality. The current within-host mathematical modeling study addresses the optimal drug regimen and efficacy of combination therapies in the treatment of COVID-19. The drugs/interventions considered include Arbidol, Remdesivir, Interferon and Lopinavir/ritonavir. It is concluded that these drugs, when administered singly or in combination, reduce the number of infected cells and viral load. (...) Four scenarios dealing with the administration of a single drug, two drugs, three drugs and all four are discussed. In all these scenarios, the optimal drug regimen is proposed based on two methods. In the first method, these medical interventions are modeled as control interventions and a corresponding objective function and optimal control problem are formulated. In this framework, the optimal drug regimen is derived. Later, using the comparative effectiveness method, the optimal drug regimen is derived based on the basic reproduction number and viral load. The average number of infected cells and viral load decreased the most when all four drugs were used together. On the other hand, the average number of susceptible cells decreased the most when Arbidol was administered alone. The basic reproduction number and viral load decreased the most when all four interventions were used together, confirming the previously obtained finding of the optimal control problem. The results of this study can help physicians make decisions about the treatment of the life-threatening COVID-19 infection. (shrink)

In refutation of Cajetan, the sixteenth century commentator who is still considered an authority on Thomas' doctrine of analogy, it is argued that "the analogy of names is, for St. Thomas, a logical intention, and in speaking of it we must observe the general rule that the logical and real orders must not be confused. St. Thomas does not see any peculiar significance of analogy for metaphysics--apart, i.e., from the significance it has for science and ordinary discourse." The thesis is (...) closely argued for and painstakingly documented.--A. P. D. M. (shrink)

Employing the tools of logical analysis, Åquist presents a very careful, though cumbrously formalistic, reassessment of Price's Review of the Principal Questions in Morals, a treatise which he considers as the best in its field before Sidgwick and Moore.--A. P. D. M.

An up-to-date exposition and critique of classical and modern philosophies of mathematics leads to the author's thesis: applied mathematics with its perceptual, inexact concepts is logically disconnected from pure mathematics which is idealized and exact. The author introduces the notion of non-unique synthetic a priori propositions and explores the differences and similarities between the logic of exact and that of inexact concepts. A lucid and stimulating essay which combines accuracy and sophistication with a minimum of technical language.--A. P. D. M.

Hermeneutics, the Bible and Literary Criticism. Edited by Ann Loades and Michael McLain.The Craft of Theology: From Symbol to System. By Avery Dulles.The Shape of Soreriology. By John McIntyre.Not the Cross But the Crucfied. By H.‐E. Mertens.Verbum Curo: An Encyclopedia on Jesus, the Christ. By Michael O'Carroll.The Search for the Origins of Christian Worship: Sources and Methods for the Study of the Early Liturgy. By Paul Bradshaw.Worship: Initiation and the Churches. By Leonel L. Mitchell.The Eucharistic Mystery: Revitalizing the Tradition. (...) By David Power.Church of Churches: The Ecclesiology of Communion. By J.‐M. Tillard.God and History, Aspects of British Theology 1875‐1914. By Peter Hinchliff.Clear Heads and Holy Hearts: The Religious and Theological Ideal of John Henry Newman. By Terrence Merrigan.The Desert Fathers on Monastic Community. By Graham Gould.John Moschos, ‘The Spiritual Meadow’. Introduction, translation and notes by John Wortley.A Gentle Touch. By David Pailin.The Eye of the Storm: Spiritual Resources for rhe Pursuit of Justice. By Kenneth Leech.The Church and the Arts. Edited by Diana Wood.Anti‐Christian Polemic in Early Islam: Abu Isa al‐Warraq's ‘Against the Trinity’. Edited by David Thomas.Bernardus Magister: Papers Presented at the Nonacentenary Celebration of the Birth of St Bernard of Clairvaux. Edited by John R. Sommerfeldt.Church and City 1000‐1500: Essays in Honour of Christopher Brooke. Edited by David Abulafia, Michael Franklin and Miri Rubin.‘Piers Plowman’ and the Problem of Belief. By Britton J. Harwood.Ignutius of Luyola: The Psychology of a Saint. By W. W. Meissner.Jerome Naahl, S. J., 1507‐1580: Tracking the First Generation of Jesuits. By William V. Bangert, edited and completed by Thomas M. McCoog.From Bishop to Witch: The System of the Sacred in Early Modern Terra d'Otranto. By David Gentilcore.Civic Politics in the Rome of Urban VIII. By Laurie Nussdorfer.Michel de Montaigne: The Complete Essays. Translated by M. A. Screech.Montaigne and Melancholy: The Wisdom of the ‘Essays’. By M. A. Screech.Religion and Philosophy. Edited by Martin Warner.What is Faith? Essays in the Philosophy of Religion. By Anthony Kenny.Truth and Hisroriciry. By Richard Campbell. (shrink)

The central insight of Darwin's Origin of Species is that evolution is an ecological phenomenon, arising from the activities of organisms in the 'struggle for life'. By contrast, the Modern Synthesis theory of evolution, which rose to prominence in the twentieth century, presents evolution as a fundamentally molecular phenomenon, occurring in populations of sub-organismal entities - genes. After nearly a century of success, the Modern Synthesis theory is now being challenged by empirical advances in the study of organismal development and (...) inheritance. In this important study, D. M. Walsh shows that the principal defect of the Modern Synthesis resides in its rejection of Darwin's organismal perspective, and argues for 'situated Darwinism': an alternative, organism-centred conception of evolution that prioritises organisms as adaptive agents. His book will be of interest to scholars and advanced students of evolutionary biology and the philosophy of biology. (shrink)

The text is divided into four chapters: 1.0 Metaphysics, transcendental philosophy and analytic philosophy; 2.0 The senses of being ; 3.0 Being and existence ; and 4.0 Modalities. After a defense of contemporary analytic philosophy against the usual charge of its supposedly superficial character and its lack of philosophical significance, Llano offers a thoughtful reading of Wittgenstein against his ancient, medieval and Kantian scholastic background. Following Gilson's historical analysis, Llano diagnoses a "tendency to reflect upon concepts with the risk of (...) forgetting the real things whose natures these concepts represent.... While the scholasticism most directly bound to Aristotle kept the consideration of real, concrete being firmly in view, Duns Scotus--in a direction already pointed out by Avicenna--was completely occupied with the concept of pure being ; a concept which, by being abstract, was understood as univocal. This perspective led him to 'prescind' from the actual reality of things, i.e., from their real existence; because, although existence itself is a notion or ratio knowable in the object, it is nevertheless required as actually belonging to the object in so far as it is knowable: 'existentia non est per se ratio obiecti, ut scibile est'". Against this background, being is taken as intelligibility, involving a relationship to the understanding that logicizes the meaning of being itself so that "the formal-essential dimension takes unto itself the whole weight of reality" and "esse is reduced to a quasi-accidental mode of the essence", which comes to be thematized in its own right as "the real modality, until a linguistic analysis, which can accept only the logical modality, passing through the logico-transcendental mediation of the gnoseological modality". Being is accordingly progressively "reabsorbed into human thought and later into various anthropological dimensions ". Section 1.3, "Toward a realist semantics," starts from Frege's attack on psychologism in the Foundations of Arithmetic and leads to a reinstatement of Aristotelian semantics in section 1.4, "Word and concept." Chapter 2 deals with the standard topics: 2.1, Predication, identity, existence; 2.2, being in propositions and being in reality; 2.3, accidental being ; and 2.4, being as it pertains to truth. Chapter 3 on being and existence suggests the thought-provoking comparison: as natura is to suppositum in Aquinas, so is Begriff to Gegenstand in Frege. Chapter 4, on the modalities of being, gets to the heart of the metaphysical issue of what happens when one of the modalities of being is substituted for being as the foundation of metaphysics. In Section 4.1, on actuality and facticity, Llano deftly centers attention on Heidegger's Grundprobleme der Phänomenologie, where Heidegger maintains that the Thomistic notion of actus essendi is merely another instance of the forgetfulness of being. Llano rightly judges that Heidegger's understanding of an opposition between essence as one thing and existence as another is derived from a position of Giles of Rome and has nothing to do with the position of Aquinas himself. Llano cites Avicenna roughly five times as often as he does Giles of Rome; Heidegger, apparently relying on hearsay reports, mentions Avicenna only once in the Grundprobleme der Phänomenologie, without citing any text, and mentions Giles of Rome three times, citing only one text. Heidegger uses a late scholastic as his authority for discrediting Aquinas. Llano quotes some of the explicit Thomistic criticisms against Avicenna including one that Heidegger partially omits ; the passage Heidegger suppresses begins "Opinio Avicennae fuit...." Though rhetorically subtle, Llano's clearly and forcefully written book is loaded with philosophical insights, bridges conversational gaps between analysts and phenomenologists, and offers a glimpse at some of the most important medieval notions sedimented within contemporary philosophy.--E. M. Macierowski, Washington, D.C. (shrink)

In this important study D. M. Armstrong offers a comprehensive system of analytical metaphysics that synthesises but also develops his thinking over the last twenty years. Armstrong's analysis, which acknowledges the 'logical atomism' of Russell and Wittgenstein, makes facts the fundamental constituents of the world, examining properties, relations, numbers, classes, possibility and necessity, dispositions, causes and laws. All these, it is argued, find their place and can be understood inside a scheme of states of affairs. This is a comprehensive and (...) rigorously this-worldly account of the most general features of reality, argued from a distinctive philosophical perspective, and it will appeal to a wide readership in analytical philosophy. (shrink)

Truths are determined not by what we believe, but by the way the world is. Or so realists about truth believe. Philosophers call such theories correspondence theories of truth. Truthmaking theory, which now has many adherents among contemporary philosophers, is the most recent development of a realist theory of truth, and in this book D. M. Armstrong offers the first full-length study of this theory. He examines its applications to different sorts of truth, including contingent truths, modal truths, truths about (...) the past and the future, and mathematical truths. In a clear, even-handed and non-technical discussion he makes a compelling case for truthmaking and its importance in philosophy. His book marks a significant contribution to the debate and will be of interest to a wide range of readers working in analytical philosophy. (shrink)

In this important study D. M. Armstrong offers a comprehensive system of analytical metaphysics that synthesises but also develops his thinking over the last twenty years. Armstrong's analysis, which acknowledges the 'logical atomism' of Russell and Wittgenstein, makes facts the fundamental constituents of the world, examining properties, relations, numbers, classes, possibility and necessity, dispositions, causes and laws. All these, it is argued, find their place and can be understood inside a scheme of states of affairs. This is a comprehensive and (...) rigorously this-worldly account of the most general features of reality, argued from a distinctive philosophical perspective, and it will appeal to a wide readership in analytical philosophy. (shrink)

Breaking new ground in the debate about the relation of mind and body, David Armstrong's classic text - first published in 1968 - remains the most compelling and comprehensive statement of the view that the mind is material or physical. In the preface to this new edition, the author reflects on the book's impact and considers it in the light of subsequent developments. He also provides a bibliography of all the key writings to have appeared in the materialist debate.

In this short text, a distinguished philosopher turns his attention to one of the oldest and most fundamental philosophical problems of all: How it is that we are able to sort and classify different things as being of the same natural class? Professor Armstrong carefully sets out six major theories—ancient, modern, and contemporary—and assesses the strengths and weaknesses of each. Recognizing that there are no final victories or defeats in metaphysics, Armstrong nonetheless defends a traditional account of universals as the (...) most satisfactory theory we have.This study is written for advanced students, but as Armstrong goes considerably beyond his earlier work on this topic, it will interest professional scholars as well. Carefully plotted and clearly written, Universals is both a paradigm of exposition and a case study on the value of careful analysis of fundamental issues in philosophy. (shrink)

Working from an integration of Michael Polanyi‘s image of learning as self-destruction and Max Weber’s analysis of the ethics of scholarship, the author explores the implications of Polanyi’s argument concerning “the depth to which the... person is involved even in... an elementary heuristic effort”. In the process, the author raises questions about current expectations concerning faculty “performance” and current methods of assessing faculty success in the classroom.

Moral inversion, the fusion of skepticism and utopianism, is a preoccupying theme in Polanyi’s work from 1946 onward. In part 1, the author analyzes Polanyi’s complex account of the intellectual developments that are implicated in a cascade of inversions in which the good is lost through complicated, misguided, and unrealistic dedication to the good. Parts 2 and 3 then address two of the most basic of the objections to Polanyi’s theory voiced by Zdzislaw Najder. To Najder’s complaint that Polanyi is (...) not clear in his use of the term “moral,” the author replies that the pivotal distinction in Polanyi’s moral theory is not the moral against the intellectual, but the passions against the appetites. In considering Najder’s complaint that Polanyi’s argument represents a naive instance of ethnocentric absolutism, the author undertakes to show Polanyi’s consistency and perspectival self-awareness by focusing on Polanyi’s account of authority and dissent within a tradition, as well as on Polanyi’s treatment of persuasion as a heuristic passion. (shrink)

The globalized societies of the late twentieth and early twenty-first centuries are de-composing, according to Bernard Stiegler. This decay is expressed by breakdown in the compositional pr...

Convinced that reason is far from transparent to itself, Michael Polanyi, even in the earliest of his non-scientific texts, sets about the work of exposing the influence of unacknowledged presuppositions, commitments, and mental dispositions. Beginning in 1950 he identifies certain of those dispositions as “moral passions,” but in earlier texts he explores this feature of experience in a variety of tentative, preliminary ways that mark stages in the shaping of his moral anthropology. Set alongside “To the Peacemakers” (1917) and the (...) final section of Science, Faith and Society (1946), “Forms of Atheism” (1948) offers an instructive moment in this development. The three contrasting analyses all point toward and illuminate the mature account of moral passion (and the associated theory of moral inversion) that supersedes them. (shrink)

Ranging himself against philosophical and theological traditions that he considered “bankrupt,” William H. Poteat sought to set philosophy back on its feet by exemplifying the way one might reason philosophically from a different set of assumptions. His project can, in this respect, be usefully compared to that of F. H. Jacobi two centuries earlier. Poteat and Michael Polanyi offered attuned critiques of philosophical presuppositions and practices. Constructively, both were committed to bringing home the agent and knower who had been evacuated (...) by depersonalized and abstracted accounts of being and knowing. (shrink)

I argue that recent advances in developmental biology demonstrate the inadequacy of suborganismal mechanism. The category of the organism, construed as a ’natural purpose’ should play an ineliminable role in explaining ontogenetic development and adaptive evolution. According to Kant the natural purposiveness of organisms cannot be demonstrated to be an objective principle in nature, nor can purposiveness figure in genuine explain. I attempt to argue, by appeal to recent work on self-organization, that the purposiveness of organisms is a natural phenomenon (...) and, by appeal to the apparatus of invariance explanation, that biological purposiveness provides genuine, ineliminable biological explanations. (edited). (shrink)

Plotinus is the first Greek philosopher to hold a systematic theory of consciousness. The key feature of his theory is that it involves multiple layers of experience: different layers of consciousness occur in different levels of self. This layering of higher modes of consciousness on lower ones provides human beings with a rich experiential world, and enables human beings to draw on their own experience to investigate their true self and the nature of reality. This involves a robust notion of (...) subjectivity. However, it is a notion of subjectivity that is unique to Plotinus, and remarkably different from the Post-Cartesian tradition. Behind the plurality of terms Plotinus uses to express consciousness, and behind the plurality of entities to which Plotinus attributes consciousness, lies a theory of human consciousness. It is a Platonist theory shaped by engagement with rival schools of ancient thought. (shrink)

We draw insights from Activity Theory within the field of human-computer interaction to quantitatively measure a mobile in-store experience (MIX), which includes the suite of shopping activities and retail services that a consumer can engage in when using their mobile device in brick-and-mortar stores. We developed and validated a nine-item, formative MIX index using survey data collected from fashion consumers in the United States (n= 1,267), United Kingdom (n= 370), Germany (n= 362), and France (n= 219). As survey measures of (...) consumer engagement in omnichannel retailing using a mobile device, the index items with stronger factor loadings described in-store shopping activities whereas those with weaker factor loadings described activities related to behavioral targeting and social networking. These results suggest that retailers should give consumers the autonomy to independently find, evaluate and purchase merchandise in brick-and-mortar stores, thereby enabling them to co-create personalized shopping experiences as active participants within an omnichannel retail servicescape. Our findings also suggest that retailers should provide consumers with more authentic ways to build community and brand affiliations than mobile marketing and social media promotions. In-store activities should not simply be a migration of pre-existing e-commerce capabilities onto mobile devices. An engaging mobile in-store experience should be an amalgam of physical and digital activities that produce a seamless shopping journey and leverage the unique properties of mobile devices – ultra-portability, location sensitivity, untetheredness, and personalization. Retail executives can use the validated MIX index to prepare strategic investments in mobile technology applications and capabilities for retail stores within their omnichannel operations. The nine-item MIX index is also well-suited for consumer surveys, which also makes it an attractive measure of consumer engagement in omnichannel retailing for future academic research. (shrink)

D. M. MacKinnon; I *—The Presidential Address: Idealism and Realism: An Old Controversy Renewed, Proceedings of the Aristotelian Society, Volume 77, Issue 1, 1.

D. M. Armstrong; II—Does Knowledge Entail Belief?, Proceedings of the Aristotelian Society, Volume 70, Issue 1, 1 June 1970, Pages 21–36, https://doi.org/10.109.